Google Scholar, Khan FAY, Nasir MMH, Jalal T, Razali S, Hassan H, Asuhaimi FA, Wahab RA (2017) In vitro evaluation of porcupine bezoar extracts as anticancer agent on A549—a preliminary study. Volume 20. PubMed Google Scholar. Later, PB aqueous extract was subjected to A375 (Skin Malignant Melanoma) (IC50, cell proliferation assay) and HGF-1 (normal cell, for cytotoxicity assay) to evaluate its anticancer potential. Ng Chiew Hoong participated in the design of the study and performed the statistical analysis. In this study, porcupine bezoar is highlighted as potential anticancer agents. Contact Mr.Syaiful +6281389891852 , +601116377848 Porcupine Bezoar Medicinal Values According to Chinese medicine records, in tradition, Porcupine Bezoar had been used as medicine by hill tribes in Southern China and South-East Asia. A lifetime of grasses, herbs, bark, and other vegetation can leave little bits of indigestible matter behind in a porcupine’s digestive tract, where they occasionally congeal into a hard ball called a bezoar. ATHIRAH ROSDI, 3 No. Alfi Khatib, The materials were collected by Loh Yean Chun. Hence, the present study was performed to study PB aqueous extracts (PBAE) in vivo toxicity effects using the zebrafish embryo model. Qamar Uddin Ahmed, A bezoar is a mass found trapped in the gastrointestinal system, though it can occur in other locations. The manuscript was designed and written by Tan Chu Shan. Shakirah Razali, Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. Pharmacogn Res 9(4):366–371, Article  Arch Pathol Lab Med 104:159–161, CAS  World J Gastroenterol 20(29):9952–9970, Article  Guang Ming Daily Newspaper. However, its toxicity profile has never been thoroughly ascertained to confirm its safe nature as an efficacious traditional medicine in the treatment of cancer as well as other ailments. Alaina Yuhanis Firus Khan, Porcupine Bezoar Medical Value According to Chinese medicine records, our ancestors and some aborigines have knowledge on the medicinal values of the porcupine bezoar. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. It is a mass of ingested wild medicinal herbs and plant parts stored inside the porcupine’s internal digestive or system. Interestingly, the scientific proofs of the usage of bezoar were limited. This bezoar has been a myth to the locals. Part of Springer Nature. PB aqueous extract showed 11.68 μg/mL ± 0.67 TPC value while TFC was not detected confirming the absence of flavonoids in PB aqueous extract. Suppliyer porcupine stone / porcupine bezoar. However, limited scientific study has been carried out to verify these traditional claims. Tan, C.S., Ng, C.H., Loh, Y.C. Tara Jalal, Mohammad Syaiful Bahari Abdull Rasad. known as porcupine bezoar, a phytobezoar that is formed from the partly digested plant materials or herbs in the stomach of Himalayan porc( Hystrix brachyura )[8, The IUCN Red List of Threatened Species. PubMed  This is a preview of subscription content, log in to check access. Porcupine dates are also known as porcupine bezoar, a phytobezoar that is formed from the partly digested plant materials or herbs in the stomach of Himalayan porcupine (Hystrix brachyura) [8,10]. SUHANA MAMAT. Porcupine bezoar (PB) is used as folk medicine for various medical conditions including cancer treatment in Malaysia. Hence, in this study, porcupine bezoar (PB) aqueous extract was evaluated for its potential as a safe anticancer agent. Google Scholar, The Star Online-Newspaper (2015) Medicine shops claim wildlife products a ‘cure-all’. Their meat is considered a delicacy in countries such as Thailand, Vietnam, and Malaysia. volume 19, pages131–136(2019)Cite this article. Adv Biotechnol Microbiol 5(1):555651, Lim AX (2015) 60% Artificial Porcupine Bezoar (豪猪枣60%仿冒). A study published recently in the journal Global Ecology and Conservation tracked, for the first time, the online trade in old-world porcupines (those from the family Hystricidae in Asia and Africa). A porcupine’s diet is wide, varied, and a little hard to digest. Genuine Porcupine Bezoar Date. Malaysia Oriental Daily Newspapar. Google Scholar, Yew PN, Goh BH, Lim YY, Lee WL (2018) Gastrointestinal bezoar stones: current knowledge and future perspective on the potential of plant-derived phytobezoar in cancer treatment. Hence, in this study, porcupine bezoar (PB) aqueous extract was evaluated for … Shaida Fariza Sulaiman, Porcupine Bezoar stone is a type of globular stone-like mass occasionally Produced in a porcupine’s internal body. CAS  Porcupine bezoars (PBs) are masses of undigested calcareous concretions formed within the gastrointestinal tract. Azir Salleh, Alaina Yuhainis Firus Khan, A traditional folk medicine in Malaysia: porcupine bezoar. PLOS Negl Trop Dis 7(7):e2310, Article  https://doi.org/10.1007/s13596-019-00370-4, DOI: https://doi.org/10.1007/s13596-019-00370-4, Over 10 million scientific documents at your fingertips, Not logged in - 128.199.74.47. Alfi Khatib, However, its potential as an anticancer agent against human cancers is still poorly studied and understood. Springer, Singapore, pp 19–39, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Minden, Pulau Pinang, Malaysia, Chu Shan Tan, Chiew Hoong Ng, Yean Chun Loh & Mun Fei Yam, You can also search for this author in It has a coat of sharp spines that defend them from predators. Ridhwan Abdul Wahab. E-ISSN 2550-147X Ridhwan Abdul Wahab. Porcupine Bezoar, Klang. Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. Folia Zool 62(3):232–234, Article  Hence, in this study, porcupine bezoar (PB) aqueous extract was evaluated for … It is believed by some that the porcupine bezoar stone can be used to cure cancer, diabetes, dengue, typhoid, epilepsy, hepatitis and many more. Immediate online access to all issues from 2019. As the In … A pseudobezoar is an indigestible object introduced intentionally into the digestive system.. Porcupine is a mammalian that live in forests. JOURNAL OF BIOMEDICAL AND CLINICAL SCIENCES, 1 (Special Issue). Retrieved from http://www.enanyang.my/news/20160512/%E7%AE%AD%E7%8C%AA%E6%9E%A3%E4%B9%8B%E8%BF%B7%E6%80%9D%E5%88%98%E6%99%93%E8%88%AA/, Lunde D, Aplin K, Molur S (2008) Hystrix brachyura, Malayan Porcupine. Demand for bezoars isn’t the only threat porcupines face. p. 61. Retrieved from http://www.animalinfo.org/country/malaysia.html, Holloway WD, Lee SP, Nicholson GI (1980) The composition and dissolution of phytobezoars. This bezoar has been a myth to the locals. Faizah Abdullah Asuhaimi, However, its toxicity profile has never been thoroughly investigated to verify its safety nature. A porcupine’s diet is wide, varied, and a little hard to digest. Tax calculation will be finalised during checkout. Medicinal value of porcupine date and porcupine bezoar Based on the ancient medical books, porcupine belly, meat and glitch have medical value and are able to treat various diseases. UMMU AFIFAH FADZIR, International Islamic University Malaysia, Understanding of Anti-Cancer Properties of Neolamarckia cadamba Leaves Extract on Breast Cancer Cell, INTERNATIONAL JOURNAL OF ALLIED HEALTH SCIENCES: Vol. Genuine Porcupine bezoar is a medically potent and rare animal gall stone that is commonly found in the stomach region of a porcupine. The selling price of the porcupine bezoar in Malaysia market is around RM300–RM1000 for 500 mg. Fatimah Opeyemi Roheem, PDF | Porcupine bezoar (PB) has been previously reported to possess various medicinal properties. Retrieved from http://www.orientaldaily.com.my/s/74980, Liu XH (2016) The mystery of porcupine bezoar (箭猪枣之迷思). However, its potential as an anticancer agent against human cancers is still poorly studied and understood. Latest issue. Faizah Abdullah Asuhaimi, All authors read and approved the final manuscript. CAS  It was reported as universal medicine in ancient time. Correspondence to Ridhwan Abdul Wahab. A traditional folk medicine in Malaysia: porcupine bezoar Authors (first, second and last of 4) Chu Shan Tan; Chiew Hoong Ng; Mun Fei Yam; Content type: Review; Published: 28 March 2019; Pages: 131 - 136 The star online (Newspaper)—behind the cage. 1 No. Retrieved from https://www.thestar.com.my/news/nation/2015/08/05/medicine-shops-claim-wildlife-products-a-cureall/#Zv1MlFF3CiX0VwqB.99, Wang DQH, Carey MC (2014) Therapeutic uses of animal biles in traditional Chinese medicine: an Ethnopharmacological, biophysical chemical and medicinal review. This manuscript described has not been published before; not under consideration for publication anywhere else; and has been approved by all co-authors. However, its potential as an anticancer agent against human cancers is still poorly studied and understood. Yes, eating the (real) porcupine dates can help our body to fight and cure a lot of illness. Al’aina Yuhainis Firus Khan, Qamar Uddin Ahmed, IC50 for DPPH was found to be 0.79 μg/mL ± 0.07. Shakirah Razali, MOHAMMAD FAUZAN ZAINUDIN, There are undocumented claims that PBs have antioxidant activity and can treat cancers. A case report [ 43 ] has explained that porcupines which had bezoars suffered clinical signs of weight loss, diarrhea, and depression. There are several varieties of bezoar, some of which have inorganic constituents and others organic.The term has both a modern (medical, scientific) and a traditional usage. Firus Khan, Al'aina Yuhainis and Jalal, Tara Kamal and Abdull Rasad, Mohammad Syaiful Bahari and Hashim, Ridzwan and Abdul Wahab, Ridhwan (2016) Porcupine bezoar exhibit as anti-cancer activities on human breast adenocarcinoma cells (MCF-7). Google Scholar, Yew PN, Lee WL, Lim YY (2017) Antioxidant and intracellular reactive oxygen species/reactive nitrogen species scavenging activities of three porcupine bezoars from Hystrix brachyura. Porcupine Bezoar Extract (PBE) has been previously described to possess diverse medicinal properties. 1 No. RIDHWAN ABDUL WAHAB, The bezoar is traditionally used in South East Asia and Europe for the treatment of cancer, poisoning, dengue, typhoid, etc. This quick miracle cure is also perceived to cure cancer, epilepsy, and typhoid.This preternatural or morbid concretions formed in the bodies of porcupines are composed of several layers that look like an onion. Ancient book of Chinese medicine have been recorded, porcupine bezoar has benefits such as, 1. Porcupine bezoar Apoptosis Cell cycle arrest Anti-angiogenesis Anti-metastasis ABSTRACT Porcupine bezoar (PB) is a calcified undigested material generally found in porcupine’s(Hystrix brachyura) gastrointestinal tract. Bezoar is believed to have medicinal value is very high to the extent that it is said that a! Be made into powder and consume with warm wine effects using the zebrafish embryo model to treat diabetes,,... 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